Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | CCR9 | P51686 | 1/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2643256 | 0.83 | CCR2 (0.64) | CCR2PTGS2PTGS1CCR9GPR35 | |
| SCHEMBL27658570 | 0.82 | CCR2 (0.82) | CCR2CCR9GPR35 | |
| SCHEMBL1503984 | 0.80 | NOD2 (0.67) | CCR2PTGS2 | |
| SCHEMBL1044018 | 0.79 | CCR2 (0.62) | CCR2PTGS2PTGS1CCR9GPR35 | |
| SCHEMBL3191922 | 0.76 | CCR2 (0.76) | CCR2CCR9GPR35 | |
| SCHEMBL718533 | 0.75 | RXFP1 (0.52) | — | |
| SCHEMBL4372812 | 0.75 | CCR2 (0.60) | CCR2PLA2G4A | |
| SCHEMBL27926662 | 0.74 | CCR2 (0.73) | CCR2GPR35 | |
| SCHEMBL4537478 | 0.74 | CCR2 (0.81) | CCR2CCR9GPR35 | |
| SCHEMBL29258471 | 0.73 | CCR2 (0.60) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598398-B2 | Acyl indoles, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-20070088071-A1 | Acyl indoles, compositions containing such compounds and methods of use | MERCK SHARP & DOHME LLC | 2007-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088071-A1 | Acyl indoles, compositions containing such compounds and methods of use | GPR119, IAPP, GLP1R | CCR2 557/4885PTGS2 334/4885PLA2G4A 535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.