Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride SCHEMBL27482913 | 0.87 | L3MBTL1 (0.39) | MAPTTDP1POLBL3MBTL1MAPK1 | |
| SCHEMBL2643138 | 0.86 | ALDH1A1 (0.43) | MAPTTDP1POLBL3MBTL1MAPK1 | |
| SCHEMBL2649499 | 0.81 | HCAR3 (0.51) | MAPTPOLBMEN1KMT2ALMNA | |
| SCHEMBL7820330 | 0.81 | MAPT (0.40) | MAPTTDP1POLBL3MBTL1MAPK1 | |
| SCHEMBL7831824 | 0.80 | TP53 (0.41) | MAPTTDP1POLBL3MBTL1MAPK1 | |
| SCHEMBL2644088 | 0.80 | MEN1 (0.46) | MAPTTDP1POLBL3MBTL1MAPK1 | |
| SCHEMBL7304083 | 0.76 | L3MBTL1 (0.68) | MAPTTDP1POLBL3MBTL1MAPK1 | |
| SCHEMBL2644119 | 0.74 | HTT (0.50) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL7168043 | 0.72 | TDP1 (0.72) | MAPTTDP1POLBL3MBTL1MAPK1 | |
| SCHEMBL2643420 | 0.70 | L3MBTL1 (0.41) | MAPTTDP1POLBL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1164134-A1 | Benzimidazole compounds and their use as modulators of the GABA A receptor complex | NEUROSEARCH A/S (DK) | 2001-12-19 | — | — | EP | disclosed |
| EP-0821684-B1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2001-12-05 | — | — | EP | disclosed |
| CN-1072669-C | Benzimidazole compounds and their use as GABAAUse of receptor complex modulators | NEURORES AS (DK) | 2001-10-10 | — | — | CN | disclosed |
| US-5922724-A | Benzimidazole compounds and their use as modulators of the GABA a receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | disclosed |
| CN-1182427-A | Benzimidazole compounds and their use as modulators of GABA receptor complexes | NEUROSEARCH AS (DK) | 1998-05-20 | — | — | CN | disclosed |
| EP-0821684-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033194-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1996-10-24 | — | — | WO | disclosed |