Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27354841 | 0.81 | RECQL (0.53) | HTTALDH1A1HPGDMAPTLMNA | |
| SCHEMBL2644088 | 0.78 | MEN1 (0.46) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL2643138 | 0.76 | ALDH1A1 (0.43) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| Fluoride SCHEMBL2643534 | 0.74 | MAPT (0.42) | ALDH1A1HPGDMAPTLMNAMEN1 | |
| Fluoride SCHEMBL27482913 | 0.73 | L3MBTL1 (0.39) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL7304083 | 0.73 | L3MBTL1 (0.68) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL30480033 | 0.72 | CSNK2A1 (0.61) | ALDH1A1MAPTLMNACSNK2A1MEN1 | |
| SCHEMBL7093116 | 0.72 | CSNK2A1 (0.61) | ALDH1A1MAPTLMNACSNK2A1MEN1 | |
| SCHEMBL27359055 | 0.70 | RECQL (0.62) | HTTALDH1A1HPGDMAPTLMNA | |
| SCHEMBL7819742 | 0.69 | KDM4E (0.40) | ALDH1A1HPGDMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1164134-A1 | Benzimidazole compounds and their use as modulators of the GABA A receptor complex | NEUROSEARCH A/S (DK) | 2001-12-19 | — | — | EP | disclosed |
| EP-0821684-B1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2001-12-05 | — | — | EP | disclosed |
| US-5922724-A | Benzimidazole compounds and their use as modulators of the GABA a receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | disclosed |
| EP-0821684-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033194-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1996-10-24 | — | — | WO | disclosed |