Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 3/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 3/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL641776 | 0.82 | P2RX7 (0.40) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 | |
| SCHEMBL2199361 | 0.79 | IDO1 (0.53) | IDO1HTTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL838375 | 0.77 | CYP3A4 (0.37) | CYP3A4MAPK1 | |
| SCHEMBL641851 | 0.77 | PKM (0.50) | IDO1HTTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3296030 | 0.77 | IDO1 (0.61) | IDO1HTTCYP1A2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL2871408 | 0.76 | IDO1 (0.59) | IDO1HTTCYP1A2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL31346721 | 0.76 | IDO1 (0.59) | IDO1HTTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4686080 | 0.73 | IDO1 (0.50) | IDO1HTTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL31323976 | 0.72 | IDO1 (0.54) | IDO1HTTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL641405 | 0.72 | IDO1 (0.44) | IDO1HTTHDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196106-B2 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK & CO., INC (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1339710-B1 | 3-OXADIAZOL-5-YL-1-AMINOALKYL-1H-INDOLE DERIVATIVES | AMRAD OPERATIONS PTY LTD (AU) | 2006-03-01 | — | — | EP | disclosed |
| US-6930118-B2 | 3-Oxadiazol-5-yl-1-aminoalkyl-1h-indole derivatives | AMRAD OPERATIONS PTY. LTD. (AU) | 2005-08-16 | — | — | US | disclosed |
| US-20040097552-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. | 2004-05-20 | — | — | US | disclosed |
| EP-1339710-A4 | 3-OXADIAZOL-5-YL-1-AMINOALKYL-1H-INDOLE DERIVATIVES | AMRAD OPERATIONS PTY LTD (AU) | 2004-05-12 | — | — | EP | disclosed |
| US-20040034073-A1 | 3-Oxadiazol-5-yl-1-aminoalkyl-1h-indole derivatives | AMRAD OPERATIONS PTY. LTD. (AU) | 2004-02-19 | — | — | US | disclosed |
| EP-1339710-A1 | 3-OXADIAZOL-5-YL-1-AMINOALKYL-1H-INDOLE DERIVATIVES | Amrad Operations Pty.,Ltd. (AU) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002036590-A1 | 3-OXADIAZOL-5-YL-1-AMINOALKYL-1H-INDOLE DERIVATIVES | AMRAD OPERATIONS PTY LTD (AU) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097552-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | GLP1R, GPR119, GCGR | IDO1 810/4885HTT 3032/4885CYP1A2 1399/4885 |
| US-20040034073-A1 | 3-Oxadiazol-5-yl-1-aminoalkyl-1h-indole derivatives | CNR1, CNR2, OPRK1 | IDO1 22/4885HTT 3976/4885CYP1A2 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.