Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | STK10 | O94804 | 2/20 | 0.33 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MDM4 | O15151 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26473527 | 0.89 | HDAC4 (0.41) | CASP1HDAC4HDAC8PTGS1STK10 | |
| SCHEMBL26454568 | 0.88 | MCL1 (0.39) | CASP1ADORA2AKDM4EHPGDALDH1A1 | |
| SCHEMBL26454576 | 0.79 | P2RX3 (0.36) | STK10SLKNR1H3KDM4EHPGD | |
| SCHEMBL26454561 | 0.78 | HDAC4 (0.38) | CASP1HDAC4HDAC8PTGS1KDM4E | |
| SCHEMBL26473511 | 0.75 | TDP2 (0.45) | CASP1HDAC4HDAC8PTGS1KDM4E | |
| SCHEMBL25467806 | 0.72 | DPP4 (0.36) | PTGS1NR1H3ADORA2AKDM4EHPGD | |
| SCHEMBL12767605 | 0.72 | PTGS1 (0.49) | CASP1HDAC4HDAC8PTGS1KDM4E | |
| SCHEMBL22909125 | 0.69 | SOD1 (0.40) | STK10SLKKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL25467807 | 0.69 | HPGD (0.49) | PTGS1NR1H3KDM4EHPGDGFER | |
| SCHEMBL25467809 | 0.68 | HPGD (0.48) | PTGS1NR1H3KDM4EHPGDGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230132715-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230132715-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | CASP1 69/4885HDAC4 531/4885HDAC8 471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.