Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOD1 | P00441 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 2/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | MAOB | P27338 | 5/20 | 0.38 |
| ▸ | CASP3 | P42574 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904568 | 0.83 | MMP13 (0.39) | CASP3ALDH1A1SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL26473527 | 0.80 | HDAC4 (0.41) | STK10SLKMAOAMAOBCASP3 | |
| SCHEMBL22904554 | 0.74 | LMNA (0.44) | CASP3ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL22904147 | 0.72 | MAOB (0.38) | MAOAMAOBCASP3SMN1; SMN2LMNA | |
| SCHEMBL22904576 | 0.72 | DAO (0.50) | STK10SLKMAOAMAOBCASP3 | |
| SCHEMBL4466852 | 0.72 | KCNA3 (0.43) | ALDH1A1SMN1; SMN2L3MBTL1NPC1LMNA | |
| SCHEMBL14266924 | 0.71 | AR (0.48) | SOD1ALDH1A1L3MBTL1MAPTKDM4E | |
| SCHEMBL5506330 | 0.71 | MAOA (0.51) | STK10SLKMAOAMAOBCASP3 | |
| SCHEMBL28812042 | 0.71 | MAOA (0.59) | MAOAMAOBSMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL9488681 | 0.70 | ALDH1A1 (0.50) | SOD1ALDH1A1SMN1; SMN2L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011871-A1 | MERTK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |