Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATIC | P31939 | 2/20 | 1.00 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.57 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.48 |
| ▸ | PHLPP2 | Q6ZVD8 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24187557 | 0.89 | ATIC (0.81) | ATICGLO1RPS6KA3POLBCYP2D6 | |
| SCHEMBL9644131 | 0.85 | ATIC (0.74) | ATICGLO1RPS6KA3POLBCYP1A2 | |
| SCHEMBL15274162 | 0.84 | ATIC (0.72) | ATICGLO1RPS6KA3POLBCYP1A2 | |
| SCHEMBL29933125 | 0.82 | ATIC (0.69) | ATICGLO1RPS6KA3POLBCYP2D6 | |
| SCHEMBL2203510 | 0.82 | ATIC (0.69) | ATICGLO1RPS6KA3POLBCYP2D6 | |
| SCHEMBL31658970 | 0.82 | ATIC (0.69) | ATICGLO1RPS6KA3POLBCYP2D6 | |
| SCHEMBL2203513 | 0.82 | ATIC (0.69) | ATICGLO1RPS6KA3POLBCYP2D6 | |
| SCHEMBL12177939 | 0.81 | ATIC (0.67) | ATICGLO1CYP1A2PHLPP2HPGD | |
| SCHEMBL11411897 | 0.81 | ATIC (0.67) | ATICGLO1RPS6KA3POLBCYP2D6 | |
| SCHEMBL14026030 | 0.79 | ATIC (0.65) | ATICGLO1RPS6KA3POLBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230127304-A1 | NEW INHIBITORS FOR THE KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230127304-A1 | NEW INHIBITORS FOR THE KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230127304-A1 | NEW INHIBITORS FOR THE KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | KEAP1, HMOX1, NFE2L2 | ATIC 2705/4885GLO1 697/4885RPS6KA3 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.