Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26465563 | 0.88 | CACNA1H (0.42) | LMNAALDH1A1KDM4ETHRBSMN1; SMN2 | |
| SCHEMBL26466389 | 0.86 | CACNA1H (0.40) | LMNAALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL26466907 | 0.86 | CACNA1H (0.40) | LMNAALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL26408706 | 0.83 | CACNA1H (0.36) | POLB | |
| SCHEMBL26499134 | 0.81 | CACNA1H (0.51) | LMNAALDH1A1KDM4ETHRBSMN1; SMN2 | |
| SCHEMBL26464766 | 0.81 | LMNA (0.47) | LMNAALDH1A1KDM4ETHRBSMN1; SMN2 | |
| SCHEMBL26083427 | 0.78 | CACNA1H (0.56) | — | |
| SCHEMBL26466006 | 0.76 | CACNA1H (0.53) | LMNAALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL26466903 | 0.74 | CACNA1H (0.50) | LMNAALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL26082300 | 0.73 | CACNA1H (0.51) | LMNASMN1; SMN2MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |