Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 4/20 | 0.46 |
| ▸ | CXCR6 | O00574 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26466903 | 0.90 | CACNA1H (0.50) | CACNA1HALDH1A1MAPTKDM4ELTA4H | |
| SCHEMBL26466009 | 0.89 | CACNA1H (0.49) | CACNA1HCXCR6ALDH1A1MAPTKDM4E | |
| SCHEMBL26466909 | 0.88 | CACNA1H (0.44) | CACNA1HCXCR6ALDH1A1MAPTLTA4H | |
| SCHEMBL26466415 | 0.87 | CACNA1H (0.53) | CACNA1HCXCR6ALDH1A1LTA4HMCHR1 | |
| SCHEMBL26466233 | 0.87 | CACNA1H (0.53) | CACNA1HCXCR6ALDH1A1LTA4HMCHR1 | |
| SCHEMBL26466914 | 0.83 | L3MBTL1 (0.43) | CACNA1HCXCR6ALDH1A1MAPTKDM4E | |
| SCHEMBL26466922 | 0.81 | CACNA1H (0.41) | CACNA1HCXCR6ALDH1A1MAPTKDM4E | |
| SCHEMBL26466250 | 0.80 | HPGD (0.49) | CACNA1HALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL26466919 | 0.80 | CACNA1H (0.42) | CACNA1HALDH1A1MAPTLTA4HSMN1; SMN2 | |
| SCHEMBL26466243 | 0.80 | HPGD (0.49) | CACNA1HALDH1A1MAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |