Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 5/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 5/20 | 0.34 |
| ▸ | HTR1A | P08908 | 4/20 | 0.34 |
| ▸ | HTR1B | P28222 | 4/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3207214 | 0.76 | EPHX2 (0.34) | CXCR2HSD11B1HTR1DHTR1AHTR1B | |
| SCHEMBL5640607 | 0.75 | ALDH1A1 (0.42) | HSD11B1 | |
| SCHEMBL2649641 | 0.75 | HSD11B1 (0.32) | HSD11B1 | |
| SCHEMBL28938014 | 0.74 | CLCN2 (0.42) | HSD11B1HTR1DDRD2DRD3 | |
| SCHEMBL2646567 | 0.73 | HSD17B10 (0.46) | METAP2PTGS2PTPN1PTPN11 | |
| SCHEMBL7571254 | 0.73 | GABRA1 (0.42) | HSD11B1HTR1DHTR1AHTR1BDRD2 | |
| SCHEMBL1811629 | 0.72 | PTGS1 (0.41) | METAP2CXCR2HSD11B1PTGS1PTGS2 | |
| SCHEMBL3829429 | 0.71 | CYP3A4 (0.41) | CXCR2HSD11B1CXCR1PTGS1PTGS2 | |
| SCHEMBL27830796 | 0.71 | ALDH1A1 (0.35) | CXCR2HSD11B1CXCR1 | |
| SCHEMBL6564952 | 0.70 | TPMT (0.39) | CXCR2HSD11B1CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |
| EP-0934274-A1 | SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS | Bayer Corporation (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004528-A2 | SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS | BAYER CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |