Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2789725 | 1.00 | RORC (0.52) | RORCMAPTTHRBSIGMAR1GRIN2D | |
| SCHEMBL5226630 | 1.00 | RORC (0.52) | RORCMAPTTHRBSIGMAR1GRIN2D | |
| Hydrochloric Acid SCHEMBL3457382 | 0.99 | RORC (0.51) | RORCMAPTTHRBSIGMAR1GRIN2D | |
| Hydrochloric Acid SCHEMBL5258121 | 0.99 | RORC (0.51) | RORCMAPTTHRBSIGMAR1GRIN2D | |
| SCHEMBL7018874 | 0.90 | RORC (0.47) | RORCMAPTTHRBSIGMAR1LMNA | |
| SCHEMBL265267 | 0.90 | RORC (0.47) | RORCMAPTTHRBSIGMAR1LMNA | |
| SCHEMBL265268 | 0.90 | RORC (0.47) | RORCMAPTTHRBSIGMAR1LMNA | |
| Hydrochloric Acid SCHEMBL28415156 | 0.86 | LMNA (0.47) | RORCSIGMAR1GRIN2DGRIN3BDRD2 | |
| SCHEMBL16640421 | 0.77 | RORC (0.56) | RORCMAPTGRIN2BLMNATP53 | |
| SCHEMBL28079360 | 0.77 | RORC (0.53) | RORCMAPTSIGMAR1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105837526-A | Preparation method of important intermediate (2S, 3R)-4-benzyl-3-(4-fluorophenyl)morpholine-2-ol for aprepitant synthesis | 浙江工业大学 | 2016-08-10 | — | — | CN | claimed |
| CN-102898396-B | Method for preparing 3-(4-fluorophenyl)-4-benzyl-2-molindone | ALPHA PHARMACEUTICAL CO LTD JIANGSU PROVINCE | 2014-12-10 | — | — | CN | claimed |
| CN-102898396-A | Method for preparing 3-(4-fluorophenyl)-4-benzyl-2-molindone | ALPHA PHARMACEUTICAL CO LTD JIANGSU PROVINCE | 2013-01-30 | — | — | CN | claimed |
| US-20020002164-A1 | Morpholine and thiomorpholine tachykinin receptor antagonists | MERCK & CO., INC. | 2002-01-03 | — | — | US | claimed |
| US-6048859-A | ANTIEMETIC AGENT | MERCK & CO., INC. (US) | 2000-04-11 | — | — | US | claimed |
| EP-0577394-B1 | Morpholine and thiomorpholine tachykinin receptor antagonists | MERCK & CO INC (US) | 1999-11-10 | — | — | EP | claimed |
| EP-0748320-A1 | PRODRUGS OF MORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1996-12-18 | — | — | EP | claimed |
| WO-1995023798-A1 | PRODRUGS OF MORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-09-08 | — | — | WO | claimed |
| WO-1994000440-A1 | MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1994-01-06 | — | — | WO | claimed |
| EP-0577394-A1 | Morpholine and thiomorpholine tachykinin receptor antagonists | MERCK & CO. INC. (US) | 1994-01-05 | — | — | EP | claimed |
| US-6432953-B1 | — | — | None | — | — | US | disclosed |
| CN-105837526-A | Preparation method of important intermediate (2S, 3R)-4-benzyl-3-(4-fluorophenyl)morpholine-2-ol for aprepitant synthesis | 浙江工业大学 | 2016-08-10 | — | — | CN | disclosed |
| CN-102898396-B | Method for preparing 3-(4-fluorophenyl)-4-benzyl-2-molindone | ALPHA PHARMACEUTICAL CO LTD JIANGSU PROVINCE | 2014-12-10 | — | — | CN | disclosed |
| CN-102898396-A | Method for preparing 3-(4-fluorophenyl)-4-benzyl-2-molindone | ALPHA PHARMACEUTICAL CO LTD JIANGSU PROVINCE | 2013-01-30 | — | — | CN | disclosed |
| US-8133994-B2 | Preparation of aprepitant | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-03-13 | — | — | US | disclosed |
| WO-1995023798-A1 | PRODRUGS OF MORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-09-08 | — | — | WO | disclosed |
| WO-1995018124-A1 | SUBSTITUTED MORPHOLINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-07-06 | — | — | WO | disclosed |
| WO-1995016679-A1 | MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-06-22 | — | — | WO | disclosed |
| WO-1994000440-A1 | MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1994-01-06 | — | — | WO | disclosed |
| EP-0577394-A1 | Morpholine and thiomorpholine tachykinin receptor antagonists | MERCK & CO. INC. (US) | 1994-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020002164-A1 | Morpholine and thiomorpholine tachykinin receptor antagonists | TRPM7, TRPM2, TRPM5 | RORC 2778/4885MAPT 1058/4885THRB 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.