Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.54 |
| ▸ | NPC1 | O15118 | 8/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15505575 | 0.83 | KDM4E (0.54) | MAPK14KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL1566534 | 0.79 | MAPK1 (0.54) | RAB9ANPC1ALDH1A1HPGDNFKB1 | |
| SCHEMBL3321144 | 0.79 | RAB9A (0.49) | RAB9ANPC1RIPK2KMT2AMEN1 | |
| SCHEMBL10374723 | 0.78 | RAB9A (0.39) | RAB9ANPC1RIPK2MAPK14KMT2A | |
| SCHEMBL1884450 | 0.77 | FGFR1 (0.45) | RAB9ANPC1MAPK14KMT2AMEN1 | |
| SCHEMBL1753026 | 0.75 | NPC1 (0.63) | RAB9ANPC1RIPK2MAPK14KMT2A | |
| SCHEMBL1888378 | 0.75 | ERN1 (0.40) | RIPK2MAPK14SMN1; SMN2 | |
| SCHEMBL4034712 | 0.75 | NPBWR1 (0.41) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13407215 | 0.75 | NR4A3 (0.44) | RAB9ANPC1RIPK2POLBALDH1A1 | |
| SCHEMBL12088052 | 0.75 | NPC1 (0.50) | RAB9ANPC1RIPK2MAPK14KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
| US-6541484-B2 | Central nervous system disorders; psychological disorders | MERCK SHARP & DOHME LIMITED | 2003-04-01 | — | — | US | disclosed |
| US-20030004180-A1 | Pyrazolo-pyridine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-01-02 | — | — | US | disclosed |
| EP-1244659-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001044244-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004180-A1 | Pyrazolo-pyridine derivatives as ligands for gaba receptors | GABRA3, GABRA4, GABRB3 | RAB9A 2107/4885NPC1 3193/4885RIPK2 2196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.