Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947686 | 0.84 | MCL1 (0.58) | ALDH1A1KDM4EKMT2AMCL1AKR1C2 | |
| SCHEMBL4636514 | 0.83 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL654962 | 0.82 | GAA (0.53) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL29746555 | 0.81 | KDM4E (0.50) | KDM4EPOLBAPEX1KDREPHX2 | |
| SCHEMBL27051469 | 0.81 | CA12 (0.50) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL21518046 | 0.81 | KEAP1 (0.50) | PKMEPHX2AKR1C2AKR1C1RXRA | |
| SCHEMBL29646307 | 0.81 | KEAP1 (0.50) | PKMEPHX2AKR1C2AKR1C1RXRA | |
| SCHEMBL2711853 | 0.81 | KDM4E (0.50) | KDM4EPOLBAPEX1KDREPHX2 | |
| SCHEMBL711924 | 0.80 | KDM4E (0.59) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL1505290 | 0.79 | EPHX2 (0.41) | ALDH1A1KDM4EHPGDHSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551793-B1 | TETRAFLUOROBENZYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ACUTE AND CHRONIC NEURODEGENERATIVE DISEASES IN CENTRAL NERVOUS SYSTEM CONTAINING THE SAME | AMKOR PHARMA INC (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20090143592-A1 | Glucagon Antagonists/Inverse Agonists | NOVO NORDISK A/S (DK) | 2009-06-04 | — | — | US | disclosed |
| US-7511074-B2 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | AMKOR PHARMA, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-20080227859-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | AMKOR PHARMA, INC. (US) | 2008-09-18 | — | — | US | disclosed |
| US-7371896-B2 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | AMKOR PHARMA, INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7319160-B2 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | AMKOR PHARMA, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-20070078183-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | NEUROTECH CO., LTD. (KR) | 2007-04-05 | — | — | US | disclosed |
| EP-1551793-A4 | TETRAFLUOROBENZYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ACUTE AND CHRONIC NEURODEGENERATIVE DISEASES IN CENTRAL NERVOUS SYSTEM CONTAINING THE SAME | NEUROTECH CO LTD (KR) | 2007-04-04 | — | — | EP | disclosed |
| US-7189878-B2 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | NEUROTECH CO., LTD. (KR) | 2007-03-13 | — | — | US | disclosed |
| US-20060235239-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | NEUROTECH CO., LTD. (KR) | 2006-10-19 | — | — | US | disclosed |
| US-20050203108-A1 | Glucagon antagonists/inverse agonists | PFIZER INC | 2005-09-15 | — | — | US | disclosed |
| US-6927303-B2 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | NEUROTECH CO., LTD. (KR) | 2005-08-09 | — | — | US | disclosed |
| EP-1551793-A1 | TETRAFLUOROBENZYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ACUTE AND CHRONIC NEURODEGENERATIVE DISEASES IN CENTRAL NERVOUS SYSTEM CONTAINING THE SAME | Neurotech Co., Ltd. (KR) | 2005-07-13 | — | — | EP | disclosed |
| US-6875760-B2 | Glucagon antagonists/inverse agonists | NOVO NORDISK A/S (DK) | 2005-04-05 | — | — | US | disclosed |
| US-20040209957-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | NEUROTECH PHARMACEUTICALS CO., LTD. (KR) | 2004-10-21 | — | — | US | disclosed |
| WO-2004000786-A1 | TETRAFLUOROBENZYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ACUTE AND CHRONIC NEURODEGENERATIVE DISEASES IN CENTRAL NERVOUS SYSTEM CONTAINING THE SAME | NEUROTECH CO., LTD. (KR) | 2003-12-31 | — | — | WO | disclosed |
| US-20030220350-A1 | Glucagon antagonists/inverse agonists | PFIZER INC | 2003-11-27 | — | — | US | disclosed |
| US-6503949-B1 | Treating Type 2 diabetes, hyperglycemia, impaired glucose tolerance or obesity | NORO NORDISK A/S (DK) | 2003-01-07 | — | — | US | disclosed |
| EP-1183229-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069810-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078183-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | HTT, BDNF, APP | ALDH1A1 1111/4885KDM4E 3670/4885MAPT 12/4885 |
| US-20080227859-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | HTT, BDNF, APP | ALDH1A1 1111/4885KDM4E 3670/4885MAPT 12/4885 |
| US-20050203108-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | ALDH1A1 3968/4885KDM4E 3664/4885MAPT 4379/4885 |
| US-20090143592-A1 | Glucagon Antagonists/Inverse Agonists | GLP1R, GPR119, GCGR | ALDH1A1 3968/4885KDM4E 3664/4885MAPT 4379/4885 |
| US-20030220350-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | ALDH1A1 3968/4885KDM4E 3664/4885MAPT 4379/4885 |
| US-20060235239-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | HTT, BDNF, APP | ALDH1A1 1111/4885KDM4E 3670/4885MAPT 12/4885 |
| US-20040209957-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | HTT, BDNF, APP | ALDH1A1 1111/4885KDM4E 3670/4885MAPT 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.