SCHEMBL26513010

SCHEMBL26513010

COc1ccc(C2(c3ccc(-c4cc(-c5ccccc5)cc(-c5ccccc5)n4)cc3)C=Cc3c4c(c5ccccc5c3O2)-c2ccccc2C4(C)C)cc1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ACACA Q13085 1/20 0.39
MAPT P10636 5/20 0.39
KDM4E B2RXH2 4/20 0.39
ALDH1A1 P00352 4/20 0.39
HPGD P15428 3/20 0.39
KMT2A Q03164 1/20 0.39
LMNA P02545 1/20 0.35
HTT P42858 1/20 0.35
AURKA O14965 1/20 0.35
AURKB Q96GD4 1/20 0.35
MCL1 Q07820 1/20 0.34
FLT3 P36888 1/20 0.34
GPR84 Q9NQS5 1/20 0.34
ACP1 P24666 5/20 0.33
LTB4R Q15722 2/20 0.33
BRD4 O60885 1/20 0.33
ENPP3 O14638 1/20 0.33
ENPP1 P22413 1/20 0.33
PDK2 Q15119 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26512643 0.94 KDM4E (0.37) ACACAMAPTKDM4EALDH1A1HPGD
SCHEMBL26513013 0.94 ACACA (0.36) ACACAMAPTKDM4EALDH1A1HPGD
SCHEMBL26513005 0.93 BRD4 (0.41) ACACAMAPTKDM4EALDH1A1HPGD
SCHEMBL26513001 0.93 BRD4 (0.41) ACACAMAPTKDM4EALDH1A1HPGD
SCHEMBL25844403 0.92 GPR84 (0.34) ACACAMAPTKDM4EALDH1A1HPGD
SCHEMBL25604650 0.92 GPR84 (0.34) ACACAMAPTKDM4EALDH1A1HPGD
SCHEMBL26513004 0.91 ACACA (0.38) ACACAMAPTKDM4EALDH1A1HPGD
SCHEMBL26512994 0.90 MAPT (0.36) ACACAMAPTALDH1A1HPGDKMT2A
SCHEMBL26512791 0.90 ACACA (0.38) ACACAMAPTKDM4EALDH1A1HPGD
SCHEMBL25607147 0.89 KDM4E (0.34) MAPTKDM4EALDH1A1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230323197-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-10-12 US disclosed
US-20230323197-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-10-12 US disclosed