Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 3/20 | 0.38 |
| ▸ | GABRD | O14764 | 3/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5655473 | 0.83 | GABRP (0.35) | NPC1RAB9ASMN1; SMN2TSHRTP53 | |
| SCHEMBL5666340 | 0.75 | NLRP3 (0.39) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL5653660 | 0.72 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2TSHRKMT2A | |
| SCHEMBL5655350 | 0.72 | TGM2 (0.34) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL5654672 | 0.72 | ALDH1A1 (0.32) | NPC1RAB9ASMN1; SMN2TP53KMT2A | |
| SCHEMBL25834699 | 0.69 | GABRP (0.34) | NPC1RAB9ASMN1; SMN2TSHRTP53 | |
| SCHEMBL5940544 | 0.69 | GABRP (0.37) | NPC1RAB9ASMN1; SMN2TSHRTP53 | |
| SCHEMBL1471693 | 0.68 | GABRP (0.45) | NPC1RAB9ASMN1; SMN2TSHRTP53 | |
| SCHEMBL25835376 | 0.67 | TDP2 (0.34) | NPC1RAB9AKMT2AMEN1GABRP | |
| SCHEMBL29546450 | 0.66 | ALDH1A1 (0.52) | NPC1RAB9ASMN1; SMN2TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532120-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004014865-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |