SCHEMBL265235

SCHEMBL265235

O=[N+]([O-])c1ccc(NN(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 2/20 0.55
CRHR2 Q13324 2/20 0.55
MAPT P10636 5/20 0.54
MEN1 O00255 7/20 0.51
KMT2A Q03164 7/20 0.51
CTDSP1 Q9GZU7 1/20 0.51
POLB P06746 1/20 0.50
MGLL Q99685 1/20 0.48
MAPK1 P28482 4/20 0.48
ALDH1A1 P00352 4/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
ATM Q13315 1/20 0.47
TLR9 Q9NR96 1/20 0.47
GFER P55789 2/20 0.46
CYP1A2 P05177 1/20 0.46
HSD17B10 Q99714 1/20 0.46
PKM P14618 1/20 0.45
RAB9A P51151 1/20 0.45
TDP1 Q9NUW8 2/20 0.45
CES2 O00748 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL265122 0.82 MAPK1 (0.56) MAPTMEN1KMT2APOLBMAPK1
SCHEMBL238958 0.81 MEN1 (0.68) CRHBPCRHR2MAPTMEN1KMT2A
SCHEMBL28405878 0.80 MEN1 (0.46) CRHBPCRHR2MAPTMEN1KMT2A
Water SCHEMBL28099770 0.80 MEN1 (0.66) CRHBPCRHR2MAPTMEN1KMT2A
SCHEMBL11794586 0.78 MAPT (0.53) CRHBPCRHR2MAPTMEN1KMT2A
SCHEMBL29771491 0.77 MEN1 (0.48) CRHBPCRHR2MAPTMEN1KMT2A
SCHEMBL8928339 0.77 MEN1 (0.48) CRHBPCRHR2MAPTMEN1KMT2A
SCHEMBL293916 0.76 MAPT (0.72) CRHBPCRHR2MAPTMEN1KMT2A
SCHEMBL6373877 0.76 MEN1 (0.59) CRHBPCRHR2MAPTMEN1KMT2A
SCHEMBL12443496 0.75 CRHBP (0.57) CRHBPCRHR2MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1655070-B1 OXIDATION CATALYST ASAHI KASEI CHEMICALS CORP (JP) 2015-07-15 EP disclosed
US-8133834-B2 Oxidation catalyst ASAHI KASEI CHEMICALS CORPORATION (JP) 2012-03-13 US disclosed
US-20100069670-A1 Oxidation catalyst ASAHI KASEI CHEMICALS CORPORATION (JP) 2010-03-18 US disclosed
US-20060229471-A1 Oxidation catalyst ASAHI KASEI CHEMICALS CORPORATION (JP) 2006-10-12 US disclosed
EP-1655070-A1 OXIDATION CATALYST Asahi Kasei Chemicals Corporation (JP) 2006-05-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069670-A1 Oxidation catalyst PPOX, SOD1, HAO2 CRHBP 3125/4885CRHR2 3353/4885MAPT 3864/4885
US-20060229471-A1 Oxidation catalyst PPOX, SOD1, HAO2 CRHBP 3125/4885CRHR2 3353/4885MAPT 3864/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.