Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799856 | 0.87 | KIF11 (0.44) | TSHRALDH1A1KIF11HPGDALOX15 | |
| SCHEMBL22900080 | 0.87 | TSHR (0.41) | TSHRALDH1A1KIF11HPGDALOX15 | |
| SCHEMBL30786333 | 0.84 | TSHR (0.46) | TSHRALDH1A1KIF11HPGDALOX15 | |
| SCHEMBL1927914 | 0.84 | TSHR (0.46) | TSHRALDH1A1KIF11HPGDALOX15 | |
| SCHEMBL23759275 | 0.83 | TSHR (0.38) | TSHRALDH1A1KIF11HPGDALOX15 | |
| SCHEMBL23759247 | 0.83 | POLB (0.39) | TSHRALDH1A1KIF11HPGDALOX15 | |
| Ammonia Solution, Strong SCHEMBL486696 | 0.82 | TSHR (0.44) | TSHRALDH1A1KIF11HPGDALOX15 | |
| SCHEMBL23483450 | 0.80 | KIF11 (0.43) | TSHRALDH1A1KIF11HPGDALOX15 | |
| SCHEMBL8415470 | 0.78 | PDE2A (0.47) | TSHRKIF11MEN1MAPTKMT2A | |
| SCHEMBL22799581 | 0.78 | ALDH1A1 (0.40) | TSHRALDH1A1KIF11HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11786528-B2 | Pyrazolopyrimidine compounds as adenosine receptor antagonists | EXSCIENTIA LTD. (GB) | 2023-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11786528-B2 | Pyrazolopyrimidine compounds as adenosine receptor antagonists | ADORA1, ADORA3, ADORA2A | TSHR 258/4885ALDH1A1 849/4885KIF11 3584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.