Sugi Predict

Sugi Predict / Compounds / SCHEMBL8415470

SCHEMBL8415470

SCHEMBL8415470

Cc1ccc(C(F)(F)F)cc1C(C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ PDE2A O00408 4/20 0.47
▸ KIF11 P52732 3/20 0.44
▸ CES2 O00748 2/20 0.42
▸ NOTUM Q6P988 1/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ TAS2R14 Q9NYV8 1/20 0.37
▸ MCL1 Q07820 2/20 0.37
▸ PTPN5 P54829 1/20 0.36
▸ RAPGEF4 Q8WZA2 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25767550 0.88 PDE2A (0.38) PDE2AKIF11CES2NOTUMMEN1
SCHEMBL1538689 0.86 CES2 (0.50) PDE2AKIF11CES2NOTUMTAS2R14
SCHEMBL11999123 0.84 PDE2A (0.58) PDE2AKIF11CES2MEN1KMT2A
SCHEMBL30786333 0.84 TSHR (0.46) KIF11MEN1KMT2AMAPTTSHR
SCHEMBL1927914 0.84 TSHR (0.46) KIF11MEN1KMT2AMAPTTSHR
SCHEMBL25763032 0.83 PDE2A (0.40) PDE2AKIF11MEN1KMT2ATSHR
SCHEMBL799856 0.83 KIF11 (0.44) PDE2AKIF11CES2NOTUMMEN1
Ammonia Solution, Strong SCHEMBL486696 0.82 TSHR (0.44) KIF11MEN1KMT2AMAPTTSHR
SCHEMBL19170782 0.82 KIF11 (0.47) PDE2AKIF11CES2MEN1KMT2A
SCHEMBL21132233 0.81 PDE2A (0.34) PDE2AKIF11CES2NOTUMTAS2R14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11912822-B2 Process of manufacturing polyols DOW GLOBAL TECHNOLOGIES LLC (US) 2024-02-27 — — US disclosed
US-20230312803-A1 POLYURETHANE COMPOSITION DOW GLOBAL TECHNOLOGIES LLC 2023-10-05 — — US disclosed
US-20230309369-A1 Organic Light-Emitting Device LG CHEM, LTD. (KR) 2023-09-28 — — US disclosed
US-11765921-B2 Ionic compound, and coating composition and organic light-emitting device comprising same LG CHEM, LTD. 2023-09-19 — — US disclosed
US-11737300-B2 Coating composition and organic light-emitting device LG CHEM, LTD. (KR) 2023-08-22 — — US disclosed
US-11697650-B2 Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors Eil Therapeutics, Inc. (US) 2023-07-11 — — US disclosed
US-20230212207-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-07-06 — — US disclosed
US-20230037157-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-02-02 — — US disclosed
US-10040804-B2 Compounds targeting proteins, compositions, methods, and uses thereof BIOTHERYX, INC. (US) 2018-08-07 — — US disclosed
US-10040804-B2 Compounds targeting proteins, compositions, methods, and uses thereof BIOTHERYX, INC. (US) 2018-08-07 — — US disclosed
US-9173869-B2 Mediators of hedgehog signaling pathways, compositions and uses related thereto CURIS, INC. (US) 2015-11-03 — — US disclosed
US-20120040951-A1 HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS SUNESIS PHARMACEUTICALS, INC. 2012-02-16 — — US disclosed
US-20110077256-A1 MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO GUICHERIT OIVIN M 2011-03-31 — — US disclosed
US-7547718-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-16 — — US disclosed
US-20080125473-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-29 — — US disclosed
US-20060241172-A1 Benzodioxane and benzodioxolane derivatives and uses thereof WYETH (US) 2006-10-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125473-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 PDE2A 728/4885KIF11 2852/4885CES2 722/4885
US-20230212207-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OTC, OCIAD1 PDE2A 3853/4885KIF11 2296/4885CES2 419/4885
US-20120040951-A1 HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS BRAF, RAF1, ARAF PDE2A 3354/4885KIF11 3648/4885CES2 2975/4885
US-20060241172-A1 Benzodioxane and benzodioxolane derivatives and uses thereof HTR2C, HTR1D, HTR1A PDE2A 676/4885KIF11 4612/4885CES2 792/4885
US-11912822-B2 Process of manufacturing polyols MRPL21, RER1, PCBP1 PDE2A 4844/4885KIF11 1941/4885CES2 906/4885
US-20110077256-A1 MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO SHH, SMO, GLI1 PDE2A 2062/4885KIF11 2744/4885CES2 4572/4885
US-11765921-B2 Ionic compound, and coating composition and organic light-emitting device comprising same OR10J3, ORC3, CD59 PDE2A 3817/4885KIF11 2561/4885CES2 2606/4885
US-11697650-B2 Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors BCL2, BCL2L1, BCL2A1 PDE2A 3173/4885KIF11 4624/4885CES2 1017/4885
US-10040804-B2 Compounds targeting proteins, compositions, methods, and uses thereof CKS1B, IKZF3, EPAS1 PDE2A 3493/4885KIF11 2013/4885CES2 4804/4885
US-11737300-B2 Coating composition and organic light-emitting device CD59, CLTB, EPCAM PDE2A 3331/4885KIF11 4444/4885CES2 488/4885
US-20230037157-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES MCOLN2, MCOLN1, MCOLN3 PDE2A 3011/4885KIF11 3430/4885CES2 233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.