Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653490 | 0.99 | CYP3A4 (0.41) | CYP3A4AKR1C1PTGDR2PTGDRPTGER2 | |
| SCHEMBL2652831 | 0.83 | PTGDR2 (0.35) | CYP3A4PTGDR2PTGDR | |
| SCHEMBL2654649 | 0.82 | PTGDR2 (0.37) | CYP3A4PTGDR2PTGDRPTGER2 | |
| SCHEMBL2654413 | 0.81 | PTGDR2 (0.51) | CYP3A4PTGDR2PTGDR | |
| SCHEMBL2655512 | 0.78 | PTGDR2 (0.55) | CYP3A4PTGDR2 | |
| SCHEMBL2652827 | 0.78 | PTGS2 (0.42) | CYP3A4PTGDR | |
| SCHEMBL2653280 | 0.77 | PTGS2 (0.44) | CYP3A4PTGDR | |
| SCHEMBL2652798 | 0.74 | ALDH1A1 (0.42) | CYP3A4 | |
| SCHEMBL10418115 | 0.74 | AKR1C1 (0.51) | CYP3A4AKR1C1PTGDR2KMO | |
| SCHEMBL2653267 | 0.72 | CA2 (0.38) | CYP3A4PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |