SCHEMBL26528591

SCHEMBL26528591

CSc1ncc(C#CCCCC(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)Nc2ccc(CO)cc2)cn1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 4/20 0.42
▸ CA2 P00918 4/20 0.42
▸ MAPT P10636 6/20 0.41
▸ TDP1 Q9NUW8 6/20 0.41
▸ KDM4E B2RXH2 5/20 0.41
▸ GLA P06280 1/20 0.41
▸ GAA P10253 1/20 0.41
▸ PAX8 Q06710 1/20 0.41
▸ SIRT5 Q9NXA8 1/20 0.40
▸ NPSR1 Q6W5P4 4/20 0.39
▸ KMT2A Q03164 1/20 0.38
▸ HDAC4 P56524 3/20 0.38
▸ HDAC1 Q13547 3/20 0.38
▸ HDAC3 O15379 2/20 0.37
▸ HDAC7 Q8WUI4 2/20 0.37
▸ HDAC2 Q92769 2/20 0.37
▸ HDAC10 Q969S8 2/20 0.37
▸ HDAC11 Q96DB2 2/20 0.37
▸ HDAC8 Q9BY41 2/20 0.37
▸ HDAC6 Q9UBN7 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26111048 0.90 NMT2 (0.37) MAPTSIRT5NMT2NMT1
SCHEMBL26111054 0.90 NMT2 (0.37) MAPTSIRT5NMT2NMT1
SCHEMBL28872431 0.86 NMT2 (0.34) MAPTHDAC4HDAC1HDAC3HDAC7
SCHEMBL26528590 0.86 TDP1 (0.40) MAPTTDP1GAAPAX8NPSR1
SCHEMBL26109645 0.84 NMT2 (0.35) MAPTHDAC4HDAC1HDAC3HDAC7
SCHEMBL26109642 0.84 NMT2 (0.35) MAPTHDAC4HDAC1HDAC3HDAC7
SCHEMBL25363954 0.81 SIRT1 (0.34) SIRT5NMT2NMT1
SCHEMBL24642859 0.80 TDP1 (0.36) CA1CA2MAPTTDP1KDM4E
SCHEMBL24642716 0.80 MDM2 (0.40) CA1CA2MAPTTDP1KDM4E
SCHEMBL25363958 0.79 SIRT1 (0.37) CA1CA2SIRT5HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748843-A2 ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2026-05-27 — — EP disclosed
EP-4556026-A1 ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2025-05-21 — — EP disclosed
EP-4552654-A1 ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2025-05-14 — — EP disclosed
US-20250144229-A1 CONJUGATE OF ANTIBODY-ERIBULIN OR DERIVATIVE THEREOF, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF MEDILINK THERAPEUTICS (SUZHOU) CO., LTD. (CN) 2025-05-08 — — US disclosed
EP-4480499-A1 CONJUGATE OF ANTIBODY-ERIBULIN OR DERIVATIVE THEREOF, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2024-12-25 — — EP disclosed
US-20240108745-A1 BIOACTIVE SUBSTANCE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF MEDILINK THERAPEUTICS (SUZHOU) CO., LTD. (CN) 2024-04-04 — — US disclosed
EP-4257154-A1 BIOACTIVE SUBSTANCE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2023-10-11 — — EP disclosed
EP-4257154-A1 BIOACTIVE SUBSTANCE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2023-10-11 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250144229-A1 CONJUGATE OF ANTIBODY-ERIBULIN OR DERIVATIVE THEREOF, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF ERLIN1, WEE1, ERLIN2 CA1 2573/4885CA2 4367/4885MAPT 1794/4885
US-20240108745-A1 BIOACTIVE SUBSTANCE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF CTSL, VIP, FURIN CA1 3250/4885CA2 4620/4885MAPT 3207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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