Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.45 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497670 | 0.80 | GSK3B (0.52) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL10538440 | 0.79 | NOTUM (0.49) | IDO1TDP2HPGD | |
| SCHEMBL22347150 | 0.79 | MAP4K4 (0.49) | METAP2TDP2MEN1 | |
| SCHEMBL5562512 | 0.79 | NOTUM (0.47) | METAP2IDO1 | |
| Hydrochloric Acid SCHEMBL30015447 | 0.78 | GSK3B (0.50) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL10536966 | 0.76 | IDO1 (0.51) | IDO1MAPTHTT | |
| SCHEMBL4716316 | 0.76 | IDO1 (0.51) | IDO1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3089533 | 0.73 | AKT1 (0.59) | METAP2IDO1GABRG2GABRB3GABRA5 | |
| SCHEMBL18790699 | 0.72 | CLK1 (0.49) | ALDH1A1 | |
| SCHEMBL29546450 | 0.72 | ALDH1A1 (0.52) | METAP2IDO1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235021-A1 | Phenylpyridazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2006-10-19 | — | — | US | disclosed |
| EP-1532120-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004014865-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235021-A1 | Phenylpyridazine derivatives as ligands for gaba receptors | GABRA5, GABRA2, GABRA3 | METAP2 3096/4885IDO1 2864/4885GABRG2 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.