Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.52 |
| ▸ | CLK2 | P49760 | 2/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | CLK3 | P49761 | 1/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.52 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | AKT1 | P31749 | 2/20 | 0.47 |
| ▸ | AKT2 | P31751 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30015447 | 0.98 | GSK3B (0.50) | GSK3BCDK5CLK4DYRK1ADYRK1B | |
| SCHEMBL1691424 | 0.80 | HTR3A (0.45) | NOTUMHTR3ARETMAP4K2HRH3 | |
| SCHEMBL27844309 | 0.80 | FGFR1 (0.51) | CDK5DYRK1ADYRK1BCDK5R1FGFR1 | |
| SCHEMBL5770101 | 0.80 | MEN1 (0.46) | HPGDNOTUMHTR3AHRH3KCNH2 | |
| SCHEMBL10537216 | 0.80 | AOC3 (0.50) | CYP1A2NOTUMFGFR1HTR3AMAP4K4 | |
| SCHEMBL18790699 | 0.80 | CLK1 (0.49) | GSK3BCDK5CLK4DYRK1ADYRK1B | |
| SCHEMBL2652995 | 0.80 | METAP2 (0.47) | HPGDCSNK2A1KDM4EMAPTGABRA1 | |
| SCHEMBL22347150 | 0.80 | MAP4K4 (0.49) | MAP4K4MKNK2AURKANTRK1 | |
| SCHEMBL10538440 | 0.80 | NOTUM (0.49) | HPGDNOTUMHTR3ACDC7 | |
| SCHEMBL5562512 | 0.80 | NOTUM (0.47) | CLK4DYRK1BCYP1A2L3MBTL1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157084-B1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVE | KOWA CO (JP) | 2013-05-22 | — | — | EP | claimed |
| US-20100197698-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVE | KOWA COMPANY, LTD. (JP) | 2010-08-05 | — | — | US | claimed |
| EP-2157084-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-02-24 | — | — | EP | claimed |
| EP-0933366-B1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2005-04-06 | — | — | EP | claimed |
| US-6235739-B1 | ANTIINFLAMMATORY AGENTS; ANTIHISTAMINES; SKIN DISORDERS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-05-22 | — | — | US | claimed |
| EP-0933366-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-08-04 | — | — | EP | claimed |
| EP-0138344-A2 | Pyridazinones as beta-adrenoceptor antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-04-24 | — | — | EP | claimed |
| JP-10059950-A | — | — | None | — | — | JP | disclosed |
| US-12637426-B2 | 1-cyano-pyrrolidine compounds as USP30 inhibitors | MISSION THERAPEUTICS LIMITED (GB) | 2026-05-26 | — | — | US | disclosed |
| US-12612371-B2 | Sigma-1 receptor ligands and therapeutic uses thereof | UNIVERSITE DE STRASBOURG (FR) | 2026-04-28 | — | — | US | disclosed |
| EP-4076456-B1 | SIGMA-1 RECEPTOR LIGANDS AND THERAPEUTIC USES THEREOF | UNIV STRASBOURG (FR) | 2024-05-01 | — | — | EP | disclosed |
| EP-4077310-B1 | SIGMA-1 RECEPTOR LIGANDS AND USES THEREOF | UNIV STRASBOURG (FR) | 2024-05-01 | — | — | EP | disclosed |
| US-11807646-B2 | 4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (USP19) | ALMAC DISCOVERY LIMITED (GB) | 2023-11-07 | — | — | US | disclosed |
| WO-1997047604-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO., LTD (JP) | 1997-12-18 | — | — | WO | disclosed |
| US-4820819-A | 5-phenyl-3[2H]-pyridazinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-04-11 | — | — | US | disclosed |
| US-4820819-A | 5-phenyl-3[2H]-pyridazinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-04-11 | — | — | US | disclosed |
| US-4810705-A | BENZODIAZEPINE DERIVATIVE ANTAGONISTS | SANOFI (FR) | 1989-03-07 | — | — | US | disclosed |
| US-4678786-A | Pharmaceutical compositions having β-adrenoceptor antagonist activity employing pyridazinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-07-07 | — | — | US | disclosed |
| EP-0156734-A2 | Triazolo[4,3-b]pyridazines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1985-10-02 | — | — | EP | disclosed |
| EP-0138344-A2 | Pyridazinones as beta-adrenoceptor antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-04-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12612371-B2 | Sigma-1 receptor ligands and therapeutic uses thereof | SIGMAR1, OPRL1, OPRM1 | GSK3B 1323/4885CDK5 3379/4885CLK4 3748/4885 |
| US-20100197698-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVE | SERPINE1, MMP1, PLAT | GSK3B 1111/4885CDK5 506/4885CLK4 548/4885 |
| US-12637426-B2 | 1-cyano-pyrrolidine compounds as USP30 inhibitors | USP30, USP1, USP10 | GSK3B 1725/4885CDK5 506/4885CLK4 3230/4885 |
| US-11807646-B2 | 4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (USP19) | USP19, USP16, USP18 | GSK3B 1532/4885CDK5 1024/4885CLK4 2737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.