Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 10/20 | 0.55 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | RARA | P10276 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348393 | 0.87 | SGMS2 (0.65) | GCKSGMS2CXCR2MEN1KMT2A | |
| SCHEMBL2651714 | 0.79 | GCK (0.85) | GCKRARARARB | |
| SCHEMBL7345966 | 0.77 | GCK (0.72) | GCKSGMS2CXCR2MEN1KMT2A | |
| SCHEMBL2650209 | 0.75 | GCK (0.61) | GCKRARARARB | |
| SCHEMBL2652506 | 0.74 | GCK (0.81) | GCKCXCR2MEN1KMT2ARARA | |
| SCHEMBL8205171 | 0.74 | SGMS2 (0.76) | SGMS2MEN1KMT2AGAANPC1 | |
| SCHEMBL5430637 | 0.74 | GCK (0.73) | GCKRARARARB | |
| SCHEMBL5070732 | 0.73 | SGMS2 (0.55) | GCKSGMS2CXCR2MEN1KMT2A | |
| SCHEMBL22871247 | 0.73 | MEN1 (0.50) | MEN1KMT2AGAANPC1RAB9A | |
| SCHEMBL14505828 | 0.72 | GCK (0.60) | GCKCXCR2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697325-A1 | BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS | AstraZeneca AB (SE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005056530-A1 | BENZOYL AMINO PYRIDYL CARBOXYLIC ACID DERIVATIVES USEFUL AS GLUCOKINASE (GLK) ACTIVATORS | ASTRAZENECA AB (SE) | 2005-06-23 | — | — | WO | disclosed |