Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 5/20 | 0.55 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | GCK | P35557 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PPIA | P62937 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27613370 | 0.91 | SGMS2 (0.65) | SGMS2TMPRSS4MEN1KMT2AGCK | |
| SCHEMBL1793859 | 0.78 | GCK (0.73) | MEN1KMT2AGCKCXCR2SIRT2 | |
| SCHEMBL18132564 | 0.77 | MEN1 (0.59) | TMPRSS4MEN1KMT2AGAATDP1 | |
| SCHEMBL5065006 | 0.75 | SGMS2 (0.48) | SGMS2MEN1KMT2AGCKGAA | |
| SCHEMBL7345966 | 0.74 | GCK (0.72) | SGMS2MEN1KMT2AGCKGAA | |
| SCHEMBL31110211 | 0.74 | MEN1 (0.57) | TMPRSS4MEN1KMT2AGAATDP1 | |
| SCHEMBL2653573 | 0.73 | GCK (0.55) | SGMS2MEN1KMT2AGCKGAA | |
| SCHEMBL31665350 | 0.73 | MEN1 (0.54) | TMPRSS4MEN1KMT2AGAA | |
| SCHEMBL1967584 | 0.73 | HCAR3 (0.63) | TMPRSS4MEN1KMT2ASIRT2 | |
| SCHEMBL15824583 | 0.72 | SMPD1 (0.61) | MEN1KMT2AGCKCXCR2SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1661568-B1 | Compounds effecting Glucokinase | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | EP | disclosed |
| EP-1674097-B1 | Compounds effecting glucokinase | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | EP | disclosed |