Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 11/20 | 0.39 |
| ▸ | GSK3B | P49841 | 5/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26105967 | 0.85 | KDM4E (0.43) | CDK2CCNE1GSK3BCDK1CDK4 | |
| SCHEMBL26540318 | 0.81 | CDK2 (0.40) | CDK2CCNE1GSK3BCDK1CDK4 | |
| SCHEMBL26105035 | 0.81 | FAAH (0.44) | CDK2CCNE1GSK3BCDK1CDK4 | |
| SCHEMBL31206739 | 0.75 | KDM4E (0.31) | SMYD3 | |
| SCHEMBL17452576 | 0.71 | PSMB8 (0.49) | KMT2APSMB8PSMB9PSMB5 | |
| SCHEMBL8014330 | 0.68 | SMN1; SMN2 (0.43) | GAAALDH1A1MEN1POLBKMT2A | |
| SCHEMBL26540840 | 0.67 | CCNE1 (0.35) | CDK2CCNE1GSK3BALDH1A1MEN1 | |
| SCHEMBL24630337 | 0.66 | KDM4E (0.36) | GAAALDH1A1MEN1KMT2A | |
| SCHEMBL26964715 | 0.66 | KDM4E (0.44) | CDK2CCNE1GSK3BCDK1CDK4 | |
| SCHEMBL26964748 | 0.65 | RAB9A (0.45) | SMYD3ALDH1A1MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072096-A1 | TETRAHYDROFURAN-CONTAINING POLYCYCLIC DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | 优领医药科技(香港)有限公司 | 2023-05-04 | — | — | WO | disclosed |