Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | KDM1A | O60341 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652705 | 0.87 | TRPV3 (0.46) | MGLLKIF11FFAR1 | |
| SCHEMBL2652751 | 0.87 | TRPV3 (0.46) | MGLLKIF11FFAR1 | |
| SCHEMBL5805144 | 0.79 | PTPN1 (0.52) | PTPN1S1PR5KIF11 | |
| SCHEMBL2277268 | 0.78 | MGLL (0.46) | MAOBKDM1ASPHK2SPHK1S1PR5 | |
| SCHEMBL2277272 | 0.78 | MGLL (0.46) | MAOBKDM1ASPHK2SPHK1S1PR5 | |
| SCHEMBL2277277 | 0.78 | MGLL (0.46) | MAOBKDM1ASPHK2SPHK1S1PR5 | |
| SCHEMBL2651171 | 0.77 | PTPN1 (0.43) | PTPN1FFAR1 | |
| SCHEMBL2652083 | 0.74 | TRPV3 (0.41) | MAOBMGLLMAOAKIF11 | |
| SCHEMBL2654341 | 0.73 | TRPV3 (0.50) | MAOBKDM1A | |
| SCHEMBL2185961 | 0.72 | EPHX1 (0.50) | EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |