Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652751 | 0.80 | TRPV3 (0.46) | TRPV3GABBR2GABBR1MGLLKIF11 | |
| SCHEMBL2652705 | 0.80 | TRPV3 (0.46) | TRPV3GABBR2GABBR1MGLLKIF11 | |
| SCHEMBL2652638 | 0.79 | TRPV3 (0.46) | TRPV3GABBR2GABBR1MGLLKIF11 | |
| SCHEMBL2269629 | 0.78 | MGLL (0.43) | GABBR2GABBR1MGLLPDE2AKIF11 | |
| SCHEMBL2269517 | 0.76 | KIF11 (0.43) | TRPV3PDE2AKIF11 | |
| SCHEMBL2269549 | 0.76 | KIF11 (0.43) | TRPV3PDE2AKIF11 | |
| SCHEMBL2269544 | 0.76 | KIF11 (0.43) | TRPV3PDE2AKIF11 | |
| SCHEMBL2654112 | 0.74 | MAOB (0.45) | MGLLKIF11MAOAMAOB | |
| SCHEMBL2268127 | 0.71 | PDE2A (0.54) | PDE2AKIF11TRPV1 | |
| SCHEMBL2268129 | 0.71 | PDE2A (0.54) | PDE2AKIF11TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |