Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 11/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652705 | 0.85 | TRPV3 (0.46) | TRPV3GABBR2GABBR1MEN1MAPT | |
| SCHEMBL2652751 | 0.85 | TRPV3 (0.46) | TRPV3GABBR2GABBR1MEN1MAPT | |
| SCHEMBL2272110 | 0.79 | KDM1A (0.43) | TRPV3KDM1AMAOBGABBR2GABBR1 | |
| SCHEMBL2272113 | 0.79 | KDM1A (0.43) | TRPV3KDM1AMAOBGABBR2GABBR1 | |
| SCHEMBL2272105 | 0.79 | KDM1A (0.43) | TRPV3KDM1AMAOBGABBR2GABBR1 | |
| SCHEMBL2653111 | 0.76 | PPARD (0.40) | TRPV3MAPTMCHR1PPARD | |
| SCHEMBL2652214 | 0.74 | GCGR (0.50) | — | |
| SCHEMBL2654112 | 0.73 | MAOB (0.45) | KDM1AMAOB | |
| SCHEMBL2652638 | 0.73 | TRPV3 (0.46) | TRPV3GABBR2GABBR1MEN1KMT2A | |
| SCHEMBL10200042 | 0.71 | TRPV3 (0.47) | TRPV3GABBR2GABBR1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |