Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652751 | 1.00 | TRPV3 (0.46) | TRPV3CYP3A4MEN1LMNAHTT | |
| SCHEMBL2654112 | 0.87 | MAOB (0.45) | KIF11FFAR1MGLL | |
| SCHEMBL2654341 | 0.85 | TRPV3 (0.50) | TRPV3MEN1KMT2AGABBR2GABBR1 | |
| SCHEMBL2652638 | 0.81 | TRPV3 (0.46) | TRPV3CYP3A4MEN1LMNAHTT | |
| SCHEMBL2651171 | 0.81 | PTPN1 (0.43) | TRPV3CYP3A4MEN1KMT2AFFAR1 | |
| SCHEMBL2652083 | 0.80 | TRPV3 (0.41) | TRPV3MEN1LMNAHTTKMT2A | |
| SCHEMBL21495045 | 0.77 | EPHX2 (0.46) | MEN1KMT2AGABBR2GABBR1 | |
| SCHEMBL9540364 | 0.75 | PDE2A (0.40) | TRPV3FFAR1RPS6KB1 | |
| SCHEMBL26081058 | 0.74 | DHODH (0.50) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL966816 | 0.74 | MEN1 (0.58) | MEN1LMNAKMT2AFFAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |