Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.46 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | MTTP | P55157 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | APOB | P04114 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652705 | 0.81 | TRPV3 (0.46) | TRPV3GABBR2GABBR1KIF11MEN1 | |
| SCHEMBL2652751 | 0.81 | TRPV3 (0.46) | TRPV3GABBR2GABBR1KIF11MEN1 | |
| SCHEMBL11621257 | 0.80 | DRD2 (0.38) | TRPV3KIF11CHRM3OPRM1OPRK1 | |
| SCHEMBL2652083 | 0.79 | TRPV3 (0.41) | TRPV3GABBR2GABBR1KIF11MEN1 | |
| SCHEMBL2273226 | 0.78 | APP (0.39) | TRPV3CHRM3MTTPMGLL | |
| SCHEMBL2651171 | 0.76 | PTPN1 (0.43) | TRPV3MEN1KMT2ARXFP1CYP3A4 | |
| SCHEMBL2654341 | 0.73 | TRPV3 (0.50) | TRPV3GABBR2GABBR1MEN1KMT2A | |
| SCHEMBL10368479 | 0.72 | MEN1 (0.40) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL2654112 | 0.72 | MAOB (0.45) | KIF11MGLL | |
| SCHEMBL11856578 | 0.71 | TAS1R3 (0.40) | MEN1KMT2ASMN1; SMN2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |