Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA4 | P22748 | 3/20 | 0.36 |
| ▸ | CA6 | P23280 | 3/20 | 0.36 |
| ▸ | CA7 | P43166 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.34 |
| ▸ | CA3 | P07451 | 2/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1857913 | 0.94 | CA2 (0.43) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL3509742 | 0.83 | CPT1B (0.36) | CA12CA1CA2CA4CA6 | |
| SCHEMBL4629130 | 0.81 | CES2 (0.40) | TSHRCA2HPGDCPT1BTAS1R3 | |
| SCHEMBL2655589 | 0.79 | TSHR (0.41) | TSHRHPGDTAS1R3TAS1R1 | |
| SCHEMBL16506296 | 0.79 | KMO (0.65) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL30717807 | 0.79 | KMO (0.65) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL2162295 | 0.77 | TSHR (0.41) | TSHRCPT1BTAS1R3SRD5A2TAS1R1 | |
| SCHEMBL19618038 | 0.75 | KMO (0.49) | CA12CA1CA2CA4CA6 | |
| SCHEMBL17996737 | 0.75 | SLC6A4 (0.40) | CA12CA1CA2CA4CA6 | |
| SCHEMBL17996736 | 0.75 | SLC6A4 (0.35) | CA12CA1CA2CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293730-A1 | Tricyclo Substituted Amides | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| US-20080293730-A1 | Tricyclo Substituted Amides | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| US-20080293730-A1 | Tricyclo Substituted Amides | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
| EP-1948645-A1 | TRICYCLO SUBSTITUTED AMIDES | Prosidion Limited (GB) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007051846-A1 | TRICYCLO SUBSTITUTED AMIDES | PROSIDION LTD (GB) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007051846-A1 | TRICYCLO SUBSTITUTED AMIDES | PROSIDION LTD (GB) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293730-A1 | Tricyclo Substituted Amides | GPR119, SLC5A2, SLC5A1 | TSHR 827/4885CA12 1287/4885CA1 1355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.