Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23763006 | 0.84 | FDPS (0.43) | FDPSRIOK2HCRTR1HCRTR2GCK | |
| SCHEMBL26548519 | 0.84 | CCR1 (0.52) | FDPSMAPK14MAPK10HRH4RIOK2 | |
| SCHEMBL26548744 | 0.81 | NOS1 (0.44) | FDPSMAPK14MAPK10HRH4TP53 | |
| SCHEMBL26548751 | 0.78 | MAPK14 (0.40) | FDPSMAPK14MAPK10HRH4KDR | |
| SCHEMBL30518614 | 0.78 | AAK1 (0.49) | FDPSMAPK14RIOK2GCKABL1 | |
| SCHEMBL26550285 | 0.77 | MAPK14 (0.41) | FDPSMAPK14MAPK10HRH4KDR | |
| SCHEMBL26548746 | 0.77 | FDPS (0.48) | FDPSMAPK14MAPK10HRH4PROKR1 | |
| SCHEMBL26547682 | 0.76 | CYP2C9 (0.43) | MAPK14MAPK10HRH4KDRALDH1A1 | |
| SCHEMBL27039674 | 0.76 | RIOK2 (0.43) | FDPSRIOK2GCKABL1ALDH1A1 | |
| SCHEMBL29851369 | 0.73 | FDPS (0.59) | FDPSMAPK14MAPK10HRH4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196975-A1 | COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2023-10-12 | — | — | WO | disclosed |