SCHEMBL26547682

SCHEMBL26547682

CC(C)Nc1cc(OCC(F)(F)F)ccn1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 3/20 0.43
CYP2C19 P33261 3/20 0.43
CYP17A1 P05093 3/20 0.43
CYP1A2 P05177 3/20 0.39
ALDH1A1 P00352 2/20 0.39
MAPK14 Q16539 3/20 0.39
MAPK10 P53779 1/20 0.39
MAPT P10636 2/20 0.38
GSK3B P49841 1/20 0.38
HTR7 P34969 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
IDH2 P48735 1/20 0.37
KDM4E B2RXH2 1/20 0.37
HRH4 Q9H3N8 1/20 0.36
BRAF P15056 1/20 0.36
KDR P35968 1/20 0.36
GPR3 P46089 1/20 0.35
IGF1R P08069 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26548751 0.81 MAPK14 (0.40) CYP1A2MAPK14MAPK10HTR7HRH4
Hydrochloric Acid SCHEMBL27931970 0.81 ALDH1A1 (0.43) CYP2C9CYP2C19CYP17A1CYP1A2ALDH1A1
Hydrochloric Acid SCHEMBL28390156 0.81 ALDH1A1 (0.43) CYP2C9CYP2C19CYP17A1CYP1A2ALDH1A1
SCHEMBL26548744 0.81 NOS1 (0.44) CYP1A2MAPK14MAPK10HTR7MEN1
SCHEMBL26548519 0.77 CCR1 (0.52) MAPK14MAPK10HRH4KDR
SCHEMBL26547349 0.77 CACNA1I (0.44) CYP2C9CYP2C19CYP17A1CYP1A2ALDH1A1
SCHEMBL26550285 0.77 MAPK14 (0.41) ALDH1A1MAPK14MAPK10HTR7HRH4
SCHEMBL26550286 0.76 HTR7 (0.40) ALDH1A1MAPK14MAPK10HTR7HRH4
SCHEMBL17131648 0.76 IDH2 (0.55) CYP1A2ALDH1A1MAPK14MAPK10IDH2
SCHEMBL26550280 0.76 FDPS (0.48) ALDH1A1MAPK14MAPK10HTR7HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023196975-A1 COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE SHY THERAPEUTICS, LLC (US) 2023-10-12 WO disclosed