Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.60 |
| ▸ | USP2 | O75604 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | LMNA | P02545 | 7/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | GBA1 | P04062 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26552819 | 0.94 | GBA1 (0.59) | TSHRUSP2MEN1KMT2AMAPT | |
| SCHEMBL21664311 | 0.85 | TSHR (0.58) | TSHRUSP2MEN1KMT2AMAPT | |
| SCHEMBL26559177 | 0.83 | GBA1 (0.46) | TSHRMEN1KMT2AMAPTGBA1 | |
| SCHEMBL26556917 | 0.81 | GBA1 (0.44) | TSHRMEN1KMT2AMAPTHTT | |
| SCHEMBL26557033 | 0.80 | GBA1 (0.43) | TSHRMEN1KMT2AMAPTLMNA | |
| SCHEMBL3460145 | 0.79 | TSHR (0.71) | TSHRUSP2MEN1KMT2AMAPT | |
| SCHEMBL26551931 | 0.78 | KDM4E (0.59) | TSHRKMT2AMAPTLMNAHTT | |
| SCHEMBL26550875 | 0.78 | MAPT (0.61) | TSHRUSP2MEN1KMT2AMAPT | |
| SCHEMBL21664313 | 0.78 | GBA1 (0.57) | TSHRUSP2MEN1KMT2AMAPT | |
| SCHEMBL26559046 | 0.78 | GBA1 (0.57) | TSHRUSP2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |