Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26552819 | 0.86 | GBA1 (0.59) | GBA1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL26556917 | 0.85 | GBA1 (0.44) | GBA1TLR7MAPTCCNE2CCNE1 | |
| SCHEMBL26557033 | 0.84 | GBA1 (0.43) | GBA1TLR7MAPTCCNE2CCNE1 | |
| SCHEMBL21456821 | 0.83 | NPY5R (0.45) | GBA1TLR7MAPTCCNE2CCNE1 | |
| SCHEMBL26550810 | 0.83 | TSHR (0.60) | GBA1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL26551931 | 0.83 | KDM4E (0.59) | GBA1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL26559007 | 0.76 | KHK (0.41) | JAK3KMT2A | |
| SCHEMBL21664279 | 0.76 | GBA1 (0.42) | GBA1TLR7MAPTCCNE2CCNE1 | |
| SCHEMBL30774303 | 0.74 | L3MBTL1 (0.66) | TLR7MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL29161535 | 0.74 | L3MBTL1 (0.61) | TLR7MAPTKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |