Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | ACP1 | P24666 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26550810 | 0.94 | TSHR (0.60) | GBA1MAPTACP1TSHRMAPK1 | |
| SCHEMBL26559177 | 0.86 | GBA1 (0.46) | GBA1MAPTACP1TSHRHSD17B10 | |
| SCHEMBL26556917 | 0.84 | GBA1 (0.44) | GBA1MAPTACP1TSHRMAPK1 | |
| SCHEMBL26550875 | 0.84 | MAPT (0.61) | GBA1MAPTACP1TSHRMAPK1 | |
| SCHEMBL21664313 | 0.83 | GBA1 (0.57) | GBA1MAPTACP1TSHRMAPK1 | |
| SCHEMBL26557033 | 0.83 | GBA1 (0.43) | GBA1MAPTTSHRMAPK1HSD17B10 | |
| SCHEMBL26559046 | 0.83 | GBA1 (0.57) | GBA1MAPTACP1TSHRMAPK1 | |
| SCHEMBL11184213 | 0.83 | GBA1 (0.64) | GBA1MAPTACP1TSHRMAPK1 | |
| SCHEMBL26551931 | 0.82 | KDM4E (0.59) | GBA1MAPTTSHRHSD17B10KMT2A | |
| SCHEMBL21664311 | 0.78 | TSHR (0.58) | GBA1MAPTACP1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |