Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28021817 | 0.74 | ALDH1A1 (0.47) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3832335 | 0.71 | ALDH1A1 (0.41) | OPRM1OPRK1OPRL1MAPTMEN1 | |
| SCHEMBL27173464 | 0.71 | HDAC4 (0.43) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29275064 | 0.68 | HDAC4 (0.43) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3863243 | 0.65 | HDAC4 (0.44) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29913527 | 0.65 | HDAC4 (0.45) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL625059 | 0.65 | HDAC4 (0.45) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23232242 | 0.64 | OPRM1 (0.59) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28835152 | 0.64 | HDAC4 (0.43) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11971801 | 0.64 | HDAC4 (0.43) | HDAC4PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335777-B2 | Benzimidazole derivatives and their use for modulating the GABAA receptor complex | NEUROSEARCH A/S (DK) | 2008-02-26 | — | — | US | disclosed |
| EP-1613312-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA A RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2008-02-20 | — | — | EP | disclosed |
| US-20060148856-A1 | Benzimidazole derivatives and their use for modulating the gabaa receptor complex | ANIONA APS (DK) | 2006-07-06 | — | — | US | disclosed |
| EP-1613312-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA sb A /sb RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087137-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148856-A1 | Benzimidazole derivatives and their use for modulating the gabaa receptor complex | GABRB2, GABRB1, GABRB3 | HDAC4 394/4885PSEN1 1750/4885PSEN2 1517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.