Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.35 |
| ▸ | MMP1 | P03956 | 3/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FCER2 | P06734 | 2/20 | 0.35 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL265370 | 0.93 | MMP1 (0.39) | CCR5MMP1MMP2MMP3CYP2D6 | |
| Hydrochloric Acid SCHEMBL266228 | 0.92 | MMP1 (0.38) | CCR5MMP1MMP2MMP3CYP2D6 | |
| SCHEMBL1450242 | 0.88 | MMP1 (0.39) | CCR5OPRM1MMP1MMP2MMP3 | |
| SCHEMBL1449025 | 0.86 | REN (0.42) | CCR5MMP1MMP2MMP3REN | |
| SCHEMBL5574185 | 0.81 | HPGD (0.40) | CCR5OPRM1MMP1MMP2FCER2 | |
| SCHEMBL1449086 | 0.77 | SLC6A2 (0.41) | MMP1MMP2MMP3OPRK1REN | |
| SCHEMBL313931 | 0.77 | CTSS (0.48) | MMP1MMP2MMP3FCER2REN | |
| SCHEMBL272047 | 0.77 | CTSS (0.48) | MMP1MMP2MMP3FCER2REN | |
| SCHEMBL1449333 | 0.76 | MMP1 (0.39) | MMP1MMP2MMP3TDP1REN | |
| SCHEMBL1449031 | 0.76 | MMP3 (0.35) | MMP1MMP2MMP3CYP2D6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133864-B2 | PAR-2 agonist | KOWA COMPANY, LTD. (JP) | 2012-03-13 | — | — | US | claimed |
| EP-1864994-B1 | PAR-2 AGONIST | KOWA CO (JP) | 2011-10-26 | — | — | EP | claimed |
| US-8133864-B2 | PAR-2 agonist | KOWA COMPANY, LTD. (JP) | 2012-03-13 | — | — | US | disclosed |