Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | YTHDC1 | Q96MU7 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14725434 | 0.78 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL22889508 | 0.66 | CDK5 (0.45) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL14725435 | 0.64 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL26184821 | 0.63 | PI4KA (0.41) | PDE4APDE4BPDE4CPDE4DCDK2 | |
| SCHEMBL22889219 | 0.62 | ADORA3 (0.42) | PDE4APDE4BPDE4CPDE4DCDK2 | |
| SCHEMBL9583542 | 0.61 | MEN1 (0.51) | YTHDC1CDK2P2RY1CCNA2CCNA1 | |
| SCHEMBL23761010 | 0.60 | ADORA3 (0.43) | YTHDC1CDK2CCNA2CCNA1 | |
| SCHEMBL12702590 | 0.60 | PI4KA (0.44) | PDE4APDE4BPDE4CPDE4DTDP1 | |
| SCHEMBL9583520 | 0.59 | CDK1 (0.43) | TDP1CDK2CCNE2CCNE1CDK5 | |
| SCHEMBL24512891 | 0.59 | YTHDC1 (0.51) | PDE4APDE4BPDE4CPDE4DYTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230331751-A1 | STEREOSELECTIVE MANUFACTURE OF SELECTED PURINE PHOSPHORAMIDATES | Atea Pharmaceuticals, Inc. (US) | 2023-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230331751-A1 | STEREOSELECTIVE MANUFACTURE OF SELECTED PURINE PHOSPHORAMIDATES | NUDT1, PNP, ATIC | PDE4A 162/4885PDE4B 143/4885PDE4C 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.