Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | GNAI3 | P08754 | 9/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 9/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26748741 | 0.89 | NPC1 (0.56) | NPC1GNAI3GNAI1GNAO1CHRM2 | |
| SCHEMBL20095287 | 0.83 | GNAI3 (0.65) | NPC1GNAI3GNAI1GNAO1MAPT | |
| SCHEMBL27456325 | 0.83 | GNAI3 (0.65) | NPC1GNAI3GNAI1GNAO1MAPT | |
| SCHEMBL21471053 | 0.79 | NPC1 (0.46) | NPC1GNAI3GNAI1GNAO1CHRM2 | |
| SCHEMBL23136096 | 0.76 | NPC1 (0.47) | NPC1GNAI3GNAI1GNAO1KDM4E | |
| SCHEMBL12521994 | 0.76 | NPC1 (0.47) | NPC1GNAI3GNAI1GNAO1KDM4E | |
| SCHEMBL23795580 | 0.75 | GNAI3 (0.57) | NPC1GNAI3GNAI1GNAO1MAPT | |
| SCHEMBL23795569 | 0.75 | ITGB3 (0.46) | NPC1GNAI3GNAI1GNAO1CHRM2 | |
| SCHEMBL6043340 | 0.73 | NPC1 (0.45) | NPC1GNAI3GNAI1GNAO1CHRM2 | |
| SCHEMBL6043336 | 0.73 | NPC1 (0.45) | NPC1GNAI3GNAI1GNAO1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11638762-B2 | Targeted delivery of nicotinamide adenine dinucleotide salvage pathway inhibitors | SEAGEN INC. (US) | 2023-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11638762-B2 | Targeted delivery of nicotinamide adenine dinucleotide salvage pathway inhibitors | NAMPT, NME4, NNMT | NPC1 167/4885GNAI3 736/4885GNAI1 448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.