Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL200462 | 0.77 | GLS (0.47) | GLSBACE1TSHR | |
| SCHEMBL473047 | 0.77 | GLS (0.47) | GLSBACE1TSHR | |
| SCHEMBL1005092 | 0.77 | GLS (0.47) | GLSBACE1TSHR | |
| SCHEMBL2647395 | 0.76 | LMNA (0.47) | — | |
| SCHEMBL9460988 | 0.75 | GLS (0.46) | GLS | |
| SCHEMBL21726165 | 0.74 | GLS (0.40) | GLSBACE1GLANPSR1 | |
| SCHEMBL21726166 | 0.74 | GLS (0.40) | GLSBACE1GLANPSR1 | |
| SCHEMBL9196022 | 0.74 | GLS (0.40) | GLSBACE1GLANPSR1 | |
| SCHEMBL18914987 | 0.73 | GLS (0.47) | GLSBACE1 | |
| SCHEMBL18219056 | 0.73 | GLS (0.47) | GLSBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590336-B1 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME (US) | 2010-12-01 | — | — | EP | disclosed |
| US-20090286875-A1 | ISOCYSTENE DERIVATIVES FOR THE TREATMENT OF PAIN | PFIZER, INC. (US) | 2009-11-19 | — | — | US | disclosed |
| US-20090215825-A1 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME LLC | 2009-08-27 | — | — | US | disclosed |
| US-7572922-B2 | Substituted pyrazoles, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 2009-08-11 | — | — | US | disclosed |
| EP-1569915-A4 | SPIROCYCLIC UREAS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2007-07-11 | — | — | EP | disclosed |
| US-20060116366-A1 | Spirocyclic ureas, compositions containing such compounds and methods of use | MERCK & CO., INC. | 2006-06-01 | — | — | US | disclosed |
| US-20060084681-A1 | Substituted pyrazoles, compositions containing such compounds and methods of use | MERCK SHARP & DOHME LLC | 2006-04-20 | — | — | US | disclosed |
| EP-1590336-A2 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1569915-A2 | SPIROCYCLIC UREAS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004069158-A2 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2004-08-19 | — | — | WO | disclosed |
| WO-2004050039-A2 | SPIROCYCLIC UREAS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2004-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215825-A1 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | GLP1R, GCGR, GPR119 | GLS 47/4885BACE1 1909/4885TSHR 254/4885 |
| US-20060084681-A1 | Substituted pyrazoles, compositions containing such compounds and methods of use | GLP1R, GCGR, GPR119 | GLS 47/4885BACE1 1909/4885TSHR 254/4885 |
| US-20060116366-A1 | Spirocyclic ureas, compositions containing such compounds and methods of use | UTS2R, GLP1R, GCGR | GLS 141/4885BACE1 4655/4885TSHR 214/4885 |
| US-20090286875-A1 | ISOCYSTENE DERIVATIVES FOR THE TREATMENT OF PAIN | IDH3A, ACHE, SDHA | GLS 3046/4885BACE1 2978/4885TSHR 2185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.