Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PTPRC | P08575 | 2/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12508090 | 0.87 | SLC6A1 (0.43) | KMT2ALMNASLC6A1MEN1CYP1A2 | |
| SCHEMBL3814101 | 0.84 | CDK8 (0.43) | KMT2ASLC6A1RAB9APOLBMEN1 | |
| SCHEMBL2065269 | 0.80 | ABCC1 (0.50) | KMT2ALMNAL3MBTL1RAB9AAXL | |
| SCHEMBL8936259 | 0.77 | SLC6A1 (0.51) | KMT2ASLC6A1RAB9APTPN1PTPRC | |
| SCHEMBL1401564 | 0.76 | GPR35 (0.44) | KMT2ALMNAL3MBTL1AXLABCC1 | |
| SCHEMBL5427346 | 0.76 | ESR2 (0.43) | KMT2ALMNAL3MBTL1RAB9AAXL | |
| SCHEMBL10889896 | 0.76 | LMNA (0.47) | KMT2ALMNAL3MBTL1RAB9AAXL | |
| SCHEMBL4398553 | 0.76 | ABCC1 (0.46) | KMT2ALMNAL3MBTL1RAB9AAXL | |
| SCHEMBL26627942 | 0.76 | ALDH1A1 (0.46) | KMT2ALMNAL3MBTL1RAB9AAXL | |
| SCHEMBL27580290 | 0.76 | LMNA (0.47) | KMT2ALMNAL3MBTL1RAB9AAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2244706-A1 | GLUCOKINASE ACTIVATORS | Merck Patent GmbH (DE) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106203-A1 | GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |