Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946233 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1HPGDMAPTTSHR | |
| SCHEMBL28039022 | 0.77 | PLA2G2A (0.47) | KDM4EALDH1A1HPGDMAPTTSHR | |
| SCHEMBL23619810 | 0.77 | AKR1B1 (0.52) | ALDH1A1MAPTTSHRHSD17B10GAA | |
| SCHEMBL9543523 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1HPGDMAPTTSHR | |
| SCHEMBL3183114 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1HPGDMAPTTSHR | |
| SCHEMBL18379426 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1HPGDMAPTTSHR | |
| SCHEMBL8580446 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1HPGDMAPTTSHR | |
| SCHEMBL8636129 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1HPGDMAPTTSHR | |
| SCHEMBL698742 | 0.74 | KDM4E (0.61) | KDM4EALDH1A1HPGDMAPTTSHR | |
| SCHEMBL10923208 | 0.73 | BCAT2 (0.48) | KDM4EALDH1A1HPGDMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183229-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069810-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-11-23 | — | — | WO | disclosed |