Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 7/20 | 0.37 |
| ▸ | GSK3B | P49841 | 7/20 | 0.37 |
| ▸ | AURKA | O14965 | 4/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | GRN | P28799 | 1/20 | 0.31 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2658746 | 0.82 | GABRA1 (0.36) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2657618 | 0.80 | GABRG2 (0.52) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659863 | 0.77 | GABRA1 (0.42) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659476 | 0.77 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL341244 | 0.69 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659044 | 0.69 | GSK3A (0.34) | GSK3AGSK3BAURKAPIM1 | |
| SCHEMBL25003929 | 0.69 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2658591 | 0.69 | GABRG2 (0.37) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2657963 | 0.69 | GABRG2 (0.35) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659486 | 0.68 | GABRG2 (0.33) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030073717-A1 | Triazolo-pyridine derivatives as ligands for GABA receptors | MERCK & CO., INC. | 2003-04-17 | — | — | US | claimed |
| EP-1087968-A1 | TRIAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2001-04-04 | — | — | EP | claimed |
| WO-1999065904-A1 | TRIAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-12-23 | — | — | WO | claimed |
| US-20030073717-A1 | Triazolo-pyridine derivatives as ligands for GABA receptors | MERCK & CO., INC. | 2003-04-17 | — | — | US | disclosed |
| US-6479506-B1 | USEFUL IN THE THERAPY OF DELETERIOUS MENTAL STATES SUCH AS ANXIETY | MERCK SHARP & DOHME LTD. (GB) | 2002-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073717-A1 | Triazolo-pyridine derivatives as ligands for GABA receptors | GABRA3, GABRA4, GABRA5 | GABRA1 7/4885GABRG2 17/4885GABRB3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.