Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 12/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659649 | 0.87 | SLC40A1 (0.45) | SLC40A1ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL2660464 | 0.87 | MMP2 (0.49) | SLC40A1ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL2660438 | 0.83 | SLC40A1 (0.53) | SLC40A1MEN1KMT2ATDP1NFKBIA | |
| SCHEMBL2659772 | 0.77 | SLC40A1 (0.46) | SLC40A1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL2661534 | 0.77 | TUBB4A (0.36) | SLC40A1 | |
| SCHEMBL1654466 | 0.76 | NFKBIA (0.48) | ALDH1A1MEN1KMT2ATDP1NFKBIA | |
| SCHEMBL2660199 | 0.74 | SLC40A1 (0.46) | SLC40A1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL2661571 | 0.74 | PLA2G7 (0.35) | SLC40A1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL2662137 | 0.73 | SLC40A1 (0.54) | SLC40A1MEN1KMT2ATDP1NFKBIA | |
| SCHEMBL30925525 | 0.73 | SLC40A1 (0.80) | SLC40A1ALDH1A1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |