SCHEMBL26641237

SCHEMBL26641237

CC(C)(C)OC(=O)N1CC(F)(C#Cc2ccc(-c3ccc(OCc4ccccc4)nc3OCc3ccccc3)cc2)C1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 7/20 0.39
▸ OPRD1 P41143 1/20 0.38
▸ OPRK1 P41145 1/20 0.38
▸ CCNT1 O60563 1/20 0.36
▸ CCNA2 P20248 1/20 0.36
▸ CDK2 P24941 1/20 0.36
▸ CDK9 P50750 1/20 0.36
▸ CCNA1 P78396 1/20 0.36
▸ YAP1 P46937 2/20 0.36
▸ GPR119 Q8TDV5 3/20 0.36
▸ GRM5 P41594 1/20 0.35
▸ STS P08842 1/20 0.35
▸ ACHE P22303 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30643684 0.93 OPRD1 (0.42) PRMT5OPRD1OPRK1CCNT1CCNA2
SCHEMBL30643651 0.91 YAP1 (0.38) PRMT5OPRD1OPRK1CCNT1CCNA2
SCHEMBL26641295 0.91 YAP1 (0.38) PRMT5OPRD1OPRK1CCNT1CCNA2
SCHEMBL30643626 0.84 TLR9 (0.36) PRMT5OPRD1OPRK1CCNT1CCNA2
SCHEMBL26641553 0.83 OPRD1 (0.42) PRMT5OPRD1OPRK1CCNT1CCNA2
SCHEMBL26641523 0.83 GRM5 (0.37) GRM5
SCHEMBL26641508 0.82 OPRD1 (0.41) PRMT5OPRD1OPRK1CCNT1CCNA2
SCHEMBL30112318 0.82 ALK (0.42) PRMT5CCNT1CCNA2CDK2CDK9
SCHEMBL26641448 0.81 CYP46A1 (0.43) PRMT5OPRD1OPRK1YAP1GPR119
SCHEMBL26641379 0.81 PRMT5 (0.40) PRMT5OPRD1OPRK1CCNT1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120092003-A CDK protein degrading agents, pharmaceutical compositions and therapeutic uses 拜欧斯瑞克斯公司 2025-06-03 — — CN disclosed
WO-2023220640-A1 CDK PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS BIOTHERYX, INC. (US) 2023-11-16 — — WO disclosed
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