Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.53 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | YAP1 | P46937 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13198829 | 0.85 | SMN1; SMN2 (0.50) | PDE4BLNPEPHTTSMN1; SMN2NPC1 | |
| SCHEMBL2090388 | 0.85 | PDE4B (0.54) | ALDH1A1PDE4BLNPEPHTTSMN1; SMN2 | |
| SCHEMBL2951356 | 0.85 | LNPEP (0.48) | PDE4BLNPEPHTTSMN1; SMN2NPC1 | |
| SCHEMBL26796779 | 0.81 | HRH3 (0.48) | ALDH1A1TP53MEN1KMT2AMAPT | |
| SCHEMBL30119946 | 0.81 | HTT (0.51) | ALDH1A1PDE4BLNPEPHTTSMN1; SMN2 | |
| SCHEMBL6681189 | 0.80 | ALDH1A1 (0.61) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL21612929 | 0.78 | SMN1; SMN2 (0.53) | PDE4BLNPEPHTTSMN1; SMN2NPC1 | |
| SCHEMBL6192978 | 0.78 | GPR119 (0.51) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1781247 | 0.78 | LNPEP (0.48) | ALDH1A1PDE4BLNPEPHTTTP53 | |
| SCHEMBL31203283 | 0.78 | LNPEP (0.48) | PDE4BLNPEPHTTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260001875-A1 | AMINOPYRIMIDINYL DERIVATIVES FOR THE TREATMENT OF PARKINSON'S DISEASE | UNIV DUNDEE (GB) | 2026-01-01 | — | — | US | disclosed |
| EP-4522603-A1 | AMINOPYRIMIDINYL DERIVATIVES FOR THE TREAMENT OF PARKINSON'S DISEASE | University Of Dundee (GB) | 2025-03-19 | — | — | EP | disclosed |
| CN-119325470-A | Aminopyrimidinyl derivatives for the treatment of parkinson's disease | 邓迪大学 | 2025-01-17 | — | — | CN | disclosed |
| WO-2023218187-A1 | AMINOPYRIMIDINYL DERIVATIVES FOR THE TREAMENT OF PARKINSON'S DISEASE | UNIVERSITY OF DUNDEE (GB) | 2023-11-16 | — | — | WO | disclosed |
| EP-4276097-A1 | AMINOPYRIMIDINYL DERIVATIVES FOR THE TREAMENT OF PARKINSON'S DISEASE | University Of Dundee (GB) | 2023-11-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260001875-A1 | AMINOPYRIMIDINYL DERIVATIVES FOR THE TREATMENT OF PARKINSON'S DISEASE | LRRK2, XIAP, PARK7 | ALDH1A1 3061/4885PDE4B 996/4885LNPEP 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.