Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | MMP7 | P09237 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664323 | 0.87 | ALDH1A1 (0.50) | ALDH1A1SIGMAR1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL6664310 | 0.86 | ALDH1A1 (0.53) | ALDH1A1TP53SIGMAR1NPC1RAB9A | |
| SCHEMBL6665392 | 0.84 | ALDH1A1 (0.51) | ALDH1A1TP53SIGMAR1NPC1HPGD | |
| SCHEMBL6665368 | 0.83 | NPSR1 (0.52) | ALDH1A1TP53HPGDNPSR1KMT2A | |
| SCHEMBL6669041 | 0.83 | ALDH1A1 (0.48) | ALDH1A1TP53NPC1RAB9AHPGD | |
| SCHEMBL6664922 | 0.83 | NPSR1 (0.48) | ALDH1A1TP53HPGDNPSR1KMT2A | |
| SCHEMBL26655327 | 0.80 | ALDH1A1 (0.54) | ALDH1A1TP53SIGMAR1NPC1RAB9A | |
| SCHEMBL6680489 | 0.79 | KMT2A (0.49) | TP53NPSR1KMT2AMEN1HTT | |
| SCHEMBL6710920 | 0.79 | ALDH1A1 (0.56) | ALDH1A1TP53GRIN2BNPC1RAB9A | |
| SCHEMBL6664439 | 0.78 | CHRM3 (0.56) | TP53KMT2ACHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014425-A1 | ACTIVATORS OF SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNELS AND USE THEREOF | GLAXO GROUP LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |