Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NQO1 | P15559 | 2/20 | 0.36 |
| ▸ | POR | P16435 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 6/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19568230 | 0.77 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NQO1PORBRD4 | |
| SCHEMBL13990465 | 0.76 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL20992387 | 0.76 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2BRD4 | |
| SCHEMBL9803021 | 0.73 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2BRD4TSHRKDM4E | |
| SCHEMBL2314210 | 0.72 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL13021597 | 0.72 | — | — | |
| SCHEMBL4899883 | 0.71 | BRD4 (0.47) | ALDH1A1SMN1; SMN2BRD4TSHRKDM4E | |
| SCHEMBL5236831 | 0.71 | L3MBTL1 (0.42) | ALDH1A1SMN1; SMN2TSHRKDM4EHSD17B10 | |
| SCHEMBL5189062 | 0.71 | NAMPT (0.41) | ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5444456 | 0.71 | NAMPT (0.41) | ALDH1A1SMN1; SMN2HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016097496-A1 | USE OF EVODONE DERIVATIVES AS REPELLENT, NOVEL EVODONE DERIVATIVES AND SYNTHESIS PROCESS | CHARABOT (FR) | 2016-06-23 | — | — | WO | claimed |
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |
| CN-110804035-B | Tetrahydrobenzofuran Mannich alkali compounds, and preparation method and application thereof | 三峡大学 | 2022-11-18 | — | — | CN | disclosed |
| CN-110804035-A | Tetrahydrobenzofuran Mannich alkali compounds, and preparation method and application thereof | 三峡大学 | 2020-02-18 | — | — | CN | disclosed |
| CN-106749135-B | Substituted benzofuran formyl hydrazone analog derivative and preparation method thereof | 浙江大学 | 2019-07-19 | — | — | CN | disclosed |
| CN-106905340-B | Benzofuran fluoro flavanone derivative and preparation method thereof | 浙江大学 | 2019-02-01 | — | — | CN | disclosed |
| CN-106279082-B | Substituted furans chalcone derivative and preparation method thereof | 浙江大学 | 2019-02-01 | — | — | CN | disclosed |
| CN-106279083-B | A kind of furocoumarin analog derivative and preparation method thereof | 浙江大学 | 2019-01-08 | — | — | CN | disclosed |
| WO-2017193063-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |
| CN-106336416-A | Furan flavone derivative and preparation method thereof | 浙江大学 | 2017-01-18 | — | — | CN | disclosed |
| US-20080312435-A1 | Imine Compound | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-18 | — | — | US | disclosed |
| US-20080312435-A1 | Imine Compound | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-18 | — | — | US | disclosed |
| EP-1995240-A1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Astellas Pharma Inc. (JP) | 2008-11-26 | — | — | EP | disclosed |
| EP-1741428-A2 | Cell adhesion inhibitors | Biogen Idec MA, Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| US-20040142976-A1 | Pyridylfuran and pyridylthiophene compounds | PFIZER INC. | 2004-07-22 | — | — | US | disclosed |
| US-6696470-B2 | FOR THERAPY OF ARTHRITIS, ASTHMA, BONE RESORPTION DISEASE, CACHEXIA, CARDIOVASCULAR DISEASE, CEREBRAL MALARIA, CROHN'S DISEASE, DIABETES, FEVER OR MYALGIA DUE TO INFECTION, GOUT, GRAFT VERSUS HOST REACTION, INFLAMMATION OF ORGANS, ETC. | PFIZER INC. | 2004-02-24 | — | — | US | disclosed |
| US-20020022729-A1 | Pyridylfuran and pyridylthiophene compounds | KAWAI AKIYOSHI (JP) | 2002-02-21 | — | — | US | disclosed |
| EP-0853083-B1 | Pyridylfuran and pyridylthiophene compounds and pharmaceutical use thereof | PFIZER (US) | 2001-09-12 | — | — | EP | disclosed |
| US-6048880-A | THERAPY FOR CYTOKINE SENSITIVE DISEASES | PFIZER PHARAMACEUTICALS INC. (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0853083-A1 | Pyridylfuran and pyridylthiophene compounds and pharmaceutical use thereof | PFIZER INC. (US) | 1998-07-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312435-A1 | Imine Compound | CNR1, CNR2, HRH4 | ALDH1A1 2674/4885SMN1; SMN2 1844/4885NQO1 1815/4885 |
| US-20040142976-A1 | Pyridylfuran and pyridylthiophene compounds | MC2R, FCGR2A, OGFR | ALDH1A1 789/4885SMN1; SMN2 3438/4885NQO1 893/4885 |
| US-20020022729-A1 | Pyridylfuran and pyridylthiophene compounds | MC2R, CRHR1, NR3C2 | ALDH1A1 729/4885SMN1; SMN2 3340/4885NQO1 916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.