Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30600517 | 1.00 | HCRTR1 (0.40) | HCRTR1HCRTR2HDAC9HTTDUSP3 | |
| SCHEMBL30600526 | 0.89 | HCRTR1 (0.38) | HCRTR1HCRTR2HTTDUSP3PTPN5 | |
| SCHEMBL26675328 | 0.89 | HCRTR1 (0.38) | HCRTR1HCRTR2HTTDUSP3PTPN5 | |
| SCHEMBL29767947 | 0.87 | HTT (0.42) | HCRTR2HTTDUSP3PTPN5PTPN11 | |
| SCHEMBL26675364 | 0.87 | HTT (0.42) | HCRTR2HTTDUSP3PTPN5PTPN11 | |
| SCHEMBL26675304 | 0.85 | P2RX7 (0.36) | HCRTR1HCRTR2HTTDUSP3PTPN5 | |
| SCHEMBL30600528 | 0.85 | P2RX7 (0.36) | HCRTR1HCRTR2HTTDUSP3PTPN5 | |
| SCHEMBL26675338 | 0.85 | ENPP3 (0.42) | HTTMAPTSMN1; SMN2TP53PKM | |
| SCHEMBL30600513 | 0.82 | MAPT (0.42) | HCRTR1HCRTR2HTTDUSP3PTPN5 | |
| SCHEMBL26675311 | 0.82 | MAPT (0.42) | HCRTR1HCRTR2HTTDUSP3PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630549-B2 | Pyrazoleamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2026-05-19 | — | — | US | claimed |
| EP-4284797-A1 | PYRAZOLEAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-12-06 | — | — | EP | claimed |
| US-20230382911-A1 | PYRAZOLEAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-11-30 | — | — | US | claimed |
| WO-2022162034-A1 | PYRAZOLEAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-08-04 | — | — | WO | claimed |
| US-12630549-B2 | Pyrazoleamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2026-05-19 | — | — | US | disclosed |
| EP-4284797-A1 | PYRAZOLEAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-12-06 | — | — | EP | disclosed |
| US-20230382911-A1 | PYRAZOLEAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-11-30 | — | — | US | disclosed |
| US-20230382911-A1 | PYRAZOLEAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-11-30 | — | — | US | disclosed |
| US-20230382911-A1 | PYRAZOLEAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-11-30 | — | — | US | disclosed |
| WO-2022162034-A1 | PYRAZOLEAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382911-A1 | PYRAZOLEAMIDE DERIVATIVES | P2RY1, P2RX1, P2RX5 | HCRTR1 972/4885HCRTR2 1503/4885HDAC9 1432/4885 |
| US-12630549-B2 | Pyrazoleamide derivatives | CYP11B2, CYP11B1, ADRA1B | HCRTR1 3185/4885HCRTR2 2462/4885HDAC9 2791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.